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CD79A (基因名), B-cell antigen receptor complex-associated protein alpha chain (蛋白名), cd79a_canlf.

产品名称:

Dog CD79A/ B-cell antigen receptor complex-associated protein alpha chain CLIA Kit
b细胞抗原受体复合体相关蛋白链

货号:

U15278d

商标:

EIAab^®

监管等级:

RUO

别名:

Ig-alpha, CD79a

检测方法:

CLIA

特异性:

Natural and recombinant dog B-cell antigen receptor complex-associated protein alpha chain

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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通用注释

亚单元:

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity.

功能:

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

数据库链接

STRING:

9615.ENSCAFP00000007407

KEGG:

cfa:484483

Pfam:

PF00047

Uniprot:

P0CAN6

Dog CD79A/ B-cell antigen receptor complex-associated protein alpha chain CLIA Kit b细胞抗原受体复合体相关蛋白链

U15278d

Ig-alpha, CD79a

Dog CD79A/ B-cell antigen receptor complex-associated protein alpha chain CLIA Kit
b细胞抗原受体复合体相关蛋白链