CTSD (基因名), Cathepsin D (蛋白名), catd_human.
产品名称:
Human CTSD/ Cathepsin D CLIA Kit
组织蛋白酶D
货号:
U1280h
商标:
EIAab®
监管等级:
别名:
CPSD
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.2-12.5ng/mL
特异性:
Natural and recombinant human Cathepsin D
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Consists of a light chain and a heavy chain (PubMed:8393577, PubMed:1426530). Interacts with ADAM30; this leads to activation of CTSD (PubMed:27333034).
功能:
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
亚细胞位置:
Lysosome
Melanosome
Secreted
Extracellular space
Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
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