CALR (基因名), Calreticulin (蛋白名), calr_pig.
产品名称:
Pig CALR/ Calreticulin CLIA Kit
Calreticulin
货号:
U1486p
商标:
EIAab®
监管等级:
别名:
CRP55, Calregulin, Endoplasmic reticulum resident protein 60, HACBP, ERp60
检测方法:
CLIA
特异性:
Natural and recombinant pig Calreticulin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with GABARAP, NR3C1, PDIA3/ERp57 and TRIM21. Interacts with PPIB and SPACA9. Interacts (via P-domain) with PDIA5.
功能:
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.
亚细胞位置:
Endoplasmic reticulum lumen
Sarcoplasmic reticulum lumen
Cytoplasm
Perinuclear region
Membrane
During oocyte maturation and after parthenogenetic activation accumulates in the plasma membrane region. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (PubMed:20222029).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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