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CACNA1C (基因名), Voltage-dependent L-type calcium channel subunit alpha-1C (蛋白名), cac1c_chick.

产品名称:

Chicken CACNA1C/ Voltage-dependent L-type calcium channel subunit alpha-1C CLIA Kit

货号:

U11659c

商标:

EIAab^®

监管等级:

RUO

别名:

CHCACHA1C, Voltage-gated calcium channel subunit alpha Cav1.2

检测方法:

CLIA

特异性:

Natural and recombinant chicken Voltage-dependent L-type calcium channel subunit alpha-1C

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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产品说明书

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通用注释

亚单元:

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

功能:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

亚细胞位置:

Membrane Multi-pass membrane protein Cell membrane

数据库链接

UniGene:

Gga.525

STRING:

9031.ENSGALP00000021218

Pfam:

PF00520

Uniprot:

O73707