BCL2 (基因名), Apoptosis regulator Bcl-2 (蛋白名), bcl2_canfa.
通用注释
亚单元:
Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with FKBP8, APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Interacts with BAG1 in an ATP-dependent manner.
功能:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
亚细胞位置:
Mitochondrion outer membrane
Single-pass membrane protein
Nucleus membrane
Single-pass membrane protein
Endoplasmic reticulum membrane
Single-pass membrane protein
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