Human BCL11A/ B-cell lymphoma/leukemia 11A CLIA Kit
b细胞淋巴瘤/白血病11

货号:

U14965h

商标:

EIAab^®

监管等级:

RUO

别名:

B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, Zinc finger protein 856, EVI-9, BCL-11A, CTIP1, EVI9, KIAA1809, ZNF856

检测方法:

CLIA

特异性:

Natural and recombinant human B-cell lymphoma/leukemia 11A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human BCL11A CLIA Kit

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通用注释

亚单元:

Interacts with TFCOUP1, PIAS3, ARP1 and EAR2 (By similarity). Isoform 1, isoform 2 and isoform 3 form homodimers and heterodimers (PubMed:27453576).

功能:

Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.

亚细胞位置:

Isoform 3 Cytoplasm Nucleus Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.

数据库链接

UniGene:

Hs.370549

SMR:

Q9H165

STRING:

9606.ENSP00000338774

KEGG:

hsa:53335

MIM:

142335

Uniprot: