Bbc3 (基因名), Bcl-2-binding component 3 (蛋白名), bbc3_rat.
产品名称:
Rat Bbc3/ Bcl-2-binding component 3 CLIA Kit
Bcl-2-bindingcomponent3
货号:
U1909r
商标:
EIAab®
监管等级:
别名:
p53 up-regulated modulator of apoptosis, Puma
检测方法:
CLIA
特异性:
Natural and recombinant rat Bcl-2-binding component 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8.
功能:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Essential for ER stress-induced cell death.
亚细胞位置:
Mitochondrion
Localized to the mitochondria in order to induce cytochrome c release.
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