Bovine BAP1/ Ubiquitin carboxyl-terminal hydrolase BAP1 CLIA Kit

货号:

U14117b

商标:

EIAab^®

监管等级:

RUO

别名:

BRCA1-associated protein 1

检测方法:

CLIA

特异性:

Natural and recombinant bovine Ubiquitin carboxyl-terminal hydrolase BAP1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Bovine BAP1 CLIA Kit

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产品说明书

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通用注释

亚单元:

Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1.

功能:

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.

亚细胞位置:

Cytoplasm Nucleus Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O.

数据库链接

UniGene:

Bt.20209

SMR:

A2VDM8

STRING:

9913.ENSBTAP00000054730

KEGG:

bta:100124510

Pfam:

PF01088

Uniprot: