BAHD1 (基因名), Bromo adjacent homology domain-containing 1 protein (蛋白名), bahd1_human.
产品名称:
Human BAHD1/ Bromo adjacent homology domain-containing 1 protein CLIA Kit
货号:
U7589h
商标:
EIAab®
监管等级:
别名:
BAH domain-containing protein 1, KIAA0945
检测方法:
CLIA
特异性:
Natural and recombinant human Bromo adjacent homology domain-containing 1 protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with CBX5 (HP1 alpha), HDAC5, MBD1 and SP1. Forms a transcription silencing complex with at least CBX3 (HP1 gamma), HDAC1, HDAC2 and TRIM28. Interacts with L.monocytogenes LntA; this interaction, occurring at a late Listeria infection stage, relieves transcription repression, mostly that of interferon-stimulated genes.
功能:
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
亚细胞位置:
Nucleus
Chromosome
Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
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