Bag6 (基因名), Large proline-rich protein BAG6 (蛋白名), bag6_mouse.
产品名称:
Mouse Bag6/ Large proline-rich protein BAG6 CLIA Kit
大号富含脯氨酸蛋白BAG6
货号:
U14404m
商标:
EIAab®
监管等级:
别名:
BAG family molecular chaperone regulator 6, BCL2-associated athanogene 6, HLA-B-associated transcript 3, Protein Scythe, BAG-6, Bat3
检测方法:
CLIA
特异性:
Natural and recombinant mouse Large proline-rich protein BAG6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol (By similarity). Interacts with AIFM1 (PubMed:18056262). Interacts with HSPA2 (PubMed:18678708). Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination.
功能:
May mediate ricin-induced apoptosis.
亚细胞位置:
Cytoplasm
Cytosol
Nucleus
Secreted
Exosome
Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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