BACE1 (基因名), Beta-secretase 1 (蛋白名), bace1_bovin.
产品名称:
Bovine BACE1/ Beta-secretase 1 CLIA Kit
β分泌酶1
货号:
U0718b
商标:
EIAab®
监管等级:
别名:
Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, Beta-site APP cleaving enzyme 1
检测方法:
CLIA
特异性:
Natural and recombinant bovine Beta-secretase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6 (By similarity). Interacts with PCSK9 (By similarity). Interacts with NAT8 and NAT8B.
功能:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
亚细胞位置:
Membrane
Single-pass type I membrane protein
Golgi apparatus
Trans-Golgi network
Endoplasmic reticulum
Endosome
Cell surface
Cytoplasmic vesicle membrane
Membrane raft
Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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