Human B4GAT1/ Beta-1,4-glucuronyltransferase 1 CLIA Kit

货号:

U14124h

商标:

EIAab^®

监管等级:

RUO

别名:

I-beta-1, 3-N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1, 3-N-acetylglucosaminyltransferase, Poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1, 3-N-acetylglucosaminyltransferase 1, iGnT, B3GNT1, B3GNT6

检测方法:

CLIA

特异性:

Natural and recombinant human Beta-1,4-glucuronyltransferase 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human B4GAT1 CLIA Kit

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通用注释

亚单元:

Interacts with LARGE1 and LARGE2.

功能:

Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).

亚细胞位置:

Golgi apparatus membrane Single-pass type II membrane protein Localizes near the trans-Golgi apparatus.

数据库链接

UniGene:

Hs.8526

STRING:

9606.ENSP00000309096

KEGG:

hsa:11041

MIM:

605517

Uniprot: