Human ASAH2/ Neutral ceramidase CLIA Kit
中性ceramidase

货号:

U11205h

商标:

EIAab^®

监管等级:

RUO

别名:

Acylsphingosine deacylase 2, BCDase, LCDase, N-acylsphingosine amidohydrolase 2, Non-lysosomal ceramidase, hCD, N-CDase, HNAC1

检测方法:

CLIA

特异性:

Natural and recombinant human Neutral ceramidase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human ASAH2 CLIA Kit

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通用注释

亚单元:

N/A

功能:

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

亚细胞位置:

Cell membrane Single-pass type II membrane protein The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo.

数据库链接

UniGene:

Hs.512645

SMR:

Q9NR71

STRING:

9606.ENSP00000378897

KEGG:

hsa:56624

MIM:

611202

Pfam: