ARHGEF2 (基因名), Rho guanine nucleotide exchange factor 2 (蛋白名), arhg2_canlf.
产品名称:
Dog ARHGEF2/ Rho guanine nucleotide exchange factor 2 CLIA Kit
货号:
U14297d
商标:
EIAab®
监管等级:
别名:
Guanine nucleotide exchange factor H1, Tight junction-associated guanine nucleotide exchange factor isoform A, GEF-H1
检测方法:
CLIA
特异性:
Natural and recombinant dog Rho guanine nucleotide exchange factor 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3 (By similarity). Interacts with DYNLT1.
功能:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2 (By similarity). Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability.
亚细胞位置:
Cytoplasm
Cytoskeleton
Cytoplasm
Cell junction
Tight junction
Golgi apparatus
Cytoplasm
Cytoskeleton
Spindle
Cytoplasmic vesicle
Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Localizes to the mitotic spindle in mitotic cells, and to tight junctions in interphase cells (PubMed:12604587).
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