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A2M (基因名), Alpha-2-macroglobulin (蛋白名), A2MG_HUMAN.
产品名称:

Human A2M/ Alpha-2-macroglobulin CLIA Kit
α-2巨球蛋白

货号:

U1017h

商标:
EIAab®
监管等级:
别名:

Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007

检测方法:
CLIA
实验类型:
Sandwich
检测范围:
1.09-70ng/mL
特异性:
Natural and recombinant human Alpha-2-macroglobulin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human A2M CLIA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


Sub Unit:
Homotetramer; disulfide-linked.


Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.


Subcellular Location:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Human alpha2-macroglobulin: genotype-phenotype relation."

[2].
"Alpha-2 macroglobulin is genetically associated with Alzheimer disease."

[3].
"Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site."

[4].
"Structure of the human alpha-2 macroglobulin gene and its promotor."

[5].
"Human alpha 2-macroglobulin gene is located on chromosome 12."

[6].
"Association between haplotype -88G/25G in A2M with Alzheimer's disease."

[7].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease."

[10].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
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