Human A1CF/ APOBEC1 complementation factor CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

APOBEC1-stimulating protein, ACF, ASP

检测方法:

CLIA

检测范围:

特异性:

Natural and recombinant human APOBEC1 complementation factor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Human A1CF CLIA Kit

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通用注释

亚单元:

Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2.

功能:

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

亚细胞位置:

Nucleus Endoplasmic reticulum Cytoplasm Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.

数据库链接

UniGene:

Hs.282795

SMR:

Q9NQ94

STRING:

9606.ENSP00000282641

KEGG:

hsa:29974

Pfam:

PF00076

Uniprot: