HTR4 (基因名), 5-hydroxytryptamine receptor 4 (蛋白名), 5HT4R_PIG.
Pig HTR4/ 5-hydroxytryptamine receptor 4 CLIA Kit
5-HT-4, Serotonin receptor 4
Natural and recombinant pig 5-hydroxytryptamine receptor 4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
May interact with PATJ, MAGI2, MPP3, NOS1, SLC9A3R1, SEC23A and SNX27. May form a complex including SLC9A3R1 and EZR.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Cell membrane Multi-pass membrane protein Endosome Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. Interacts (via C-terminus) with GRK5; this interaction is promoted by 5-HT (serotonin).
"Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia."
"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus."
"Expression of serotonin receptor mRNAs in blood vessels."
"Association study of the serotoninergic system in migraine in the Spanish population."
"Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples."
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