Htr2c (基因名), 5-hydroxytryptamine receptor 2C (蛋白名), 5HT2C_RAT.
产品名称:
Rat Htr2c/ 5-hydroxytryptamine receptor 2C CLIA Kit
5-HT-2C
货号:
U10285r
商标:
EIAab®
监管等级:
别名:
5-hydroxytryptamine receptor 1C, Serotonin receptor 2C, 5-HT-1C, 5-HT-2C, 5ht1c, Htr1c
检测方法:
CLIA
特异性:
Natural and recombinant rat 5-hydroxytryptamine receptor 2C
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with MPDZ. Interacts with ARRB2.
功能:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
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