Htr2b (基因名), 5-hydroxytryptamine receptor 2B (蛋白名), 5HT2B_RAT.
产品名称:
Rat Htr2b/ 5-hydroxytryptamine receptor 2B CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
5-HT-2F, Serotonin receptor 2B, Stomach fundus serotonin receptor, 5-HT-2B, Srl
检测方法:
CLIA
特异性:
Natural and recombinant rat 5-hydroxytryptamine receptor 2B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via C-terminus) with MPDZ.
功能:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1505525, PubMed:1331748). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:22525520). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:1505525, PubMed:1331748). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). May play a role in the perception of pain (PubMed:22525520).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Synaptosome
数据库链接
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