HTR2B (基因名), 5-hydroxytryptamine receptor 2B (蛋白名), 5HT2B_PIG.
产品名称:
Pig HTR2B/ 5-hydroxytryptamine receptor 2B CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Serotonin receptor 2B, 5-HT-2B
检测方法:
CLIA
特异性:
Natural and recombinant pig 5-hydroxytryptamine receptor 2B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via C-terminus) with MPDZ.
功能:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Synaptosome
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