Htr2a (基因名), 5-hydroxytryptamine receptor 2A (蛋白名), 5HT2A_MOUSE.
产品名称:
Mouse Htr2a/ 5-hydroxytryptamine receptor 2A CLIA Kit
5-羟色胺受体2
货号:
U10283m
商标:
EIAab®
监管等级:
别名:
Serotonin receptor 2A, 5-HT-2, Htr2
检测方法:
CLIA
特异性:
Natural and recombinant mouse 5-hydroxytryptamine receptor 2A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with MPDZ and PATJ. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (By similarity). Interacts with GRM2 and DRD2; this may affect signaling.
功能:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell projection
Dendrite
Cell projection
Axon
Cytoplasmic vesicle
Membrane
Caveola
Localizes to the postsynaptic thickening of axo-dendritic synapses.
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