Htr2a (基因名), 5-hydroxytryptamine receptor 2A (蛋白名), 5HT2A_MOUSE.
Mouse Htr2a/ 5-hydroxytryptamine receptor 2A CLIA Kit
5-HT-2, Serotonin receptor 2A, Htr2
Natural and recombinant mouse 5-hydroxytryptamine receptor 2A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MPDZ and PATJ. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (By similarity). Interacts with GRM2 and DRD2; this may affect signaling.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Cell membrane Multi-pass membrane protein Cell projection Dendrite Cell projection Axon Cytoplasmic vesicle Membrane Caveola Localizes to the postsynaptic thickening of axo-dendritic synapses.
MEILCEDNIS | LSSIPNSLMQ | LGDDSRLYPN | DFNSRDANTS | EASNWTIDAE |
NRTNLSCEGY | LPPTCLSILH | LQEKNWSALL | TTVVIILTIA | GNILVIMAVS |
LEKKLQNATN | YFLMSLAIAD | MLLGFLVMPV | SMLTILYGYR | WPLPSKLCAV |
WIYLDVLFST | ASIMHLCAIS | LDRYVAIQNP | IHHSRFNSRT | KAFLKIIAVW |
TISVGISMPI | PVFGLQDDSK | VFKEGSCLLA | DDNFVLIGSF | VAFFIPLTIM |
VITYFLTIKS | LQKEATLCVS | DLSTRAKLSS | FSFLPQSSLS | SEKLFQRSIH |
REPGSYAGRR | TMQSISNEQK | ACKVLGIVFF | LFVVMWCPFF | ITNIMAVICK |
ESCNENVIGA | LLNVFVWIGY | LSSAVNPLVY | TLFNKTYRSA | FSRYIQCQYK |
ENRKPLQLIL | VNTIPTLAYK | SSQLQVGQKK | NSQEDAEPTA | NDCSMVTLGN |
QHSEEMCTDN | IETVNEKVSC | V
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."
"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."
"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."
"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."
"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."
"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."
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