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Htr2a (基因名), 5-hydroxytryptamine receptor 2A (蛋白名), 5HT2A_MOUSE.
产品名称:

Mouse Htr2a/ 5-hydroxytryptamine receptor 2A CLIA Kit
5-羟色胺受体2

货号:

U10283m

商标:
EIAab®
监管等级:
别名:

5-HT-2, Serotonin receptor 2A, Htr2

检测方法:
CLIA
特异性:
Natural and recombinant mouse 5-hydroxytryptamine receptor 2A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Htr2a CLIA Kit
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产品说明书


通用注释


Sub Unit:
Interacts with MPDZ and PATJ. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (By similarity). Interacts with GRM2 and DRD2; this may affect signaling.


Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.


Subcellular Location:
Cell membrane Multi-pass membrane protein Cell projection Dendrite Cell projection Axon Cytoplasmic vesicle Membrane Caveola Localizes to the postsynaptic thickening of axo-dendritic synapses.


该产品尚未在任何出版物中被引用。

[1].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."

[2].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."

[3].
"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."

[4].
"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."

[5].
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."

[6].
"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."

[7].
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."

[8].
"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."

[9].
"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."

[10].
"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."
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