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HTR1A (基因名), 5-hydroxytryptamine receptor 1A (蛋白名), 5HT1A_HUMAN.
产品名称:

Human HTR1A/ 5-hydroxytryptamine receptor 1A CLIA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

5-HT-1A, G-21, Serotonin receptor 1A, ADRB2RL1, ADRBRL1

检测方法:
CLIA
特异性:
Natural and recombinant human 5-hydroxytryptamine receptor 1A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human HTR1A CLIA Kit
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产品说明书


通用注释


Sub Unit:
Heterodimer; heterodimerizes with GPER1.


Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.


Subcellular Location:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."

[2].
"SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A."

[3].
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."

[4].
"Interaction between genetic polymorphisms and stressful life events in first episode depression."

[5].
"Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression."

[6].
"Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes."

[7].
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."

[8].
"Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia."

[9].
"Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders."

[10].
"Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior."
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