HTR1A (基因名), 5-hydroxytryptamine receptor 1A (蛋白名), 5HT1A_HUMAN.
产品名称:
Human HTR1A/ 5-hydroxytryptamine receptor 1A CLIA Kit
货号:
U15655h
商标:
EIAab®
监管等级:
别名:
G-21, Serotonin receptor 1A, 5-HT-1A, ADRB2RL1, ADRBRL1
检测方法:
CLIA
特异性:
Natural and recombinant human 5-hydroxytryptamine receptor 1A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Heterodimer; heterodimerizes with GPER1.
功能:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
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