Slc3a2 (基因名), 4F2 cell-surface antigen heavy chain (蛋白名), 4F2_RAT.
Rat Slc3a2/ 4F2 cell-surface antigen heavy chain CLIA Kit
4F2hc, Solute carrier family 3 member 2, CD98
Natural and recombinant rat 4F2 cell-surface antigen heavy chain
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1 (By similarity). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1.
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Apical cell membrane Single-pass type II membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localized to the plasma membrane when associated with SLC7A5 or SLC7A8 (By similarity). Localized to the placental apical membrane (By similarity). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
MSQDTEVDMK | DVELNELEPE | KQPMNAADGA | AAGEKNGLVK | IKVAEDEAEA |
GVKFTGLSKE | ELLKVAGSPG | WVRTRWALLL | LFWLGWLGML | AGAVVIIVRA |
PRCRELPVQR | WWHKGALYRI | GDLQAFVGPE | ARGIAGLKNH | LEYLSTLKVK |
GLVLGPIHKN | QKDEVNETDL | KQIDPDLGSQ | EDFKDLLQSA | KKKSIHIILD |
LTPNYKGQNA | WFLPPQADIV | ATKMKEALSS | WLQDGVDGFQ | VRDVGKLANA |
SLYLAEWQNI | TKNFSEDRLL | IAGTASSDLQ | QIVNILESTS | DLLLTSSYLS |
QPVFTGEHAE | LLVIKYLNAT | GSRWCSWSVS | QAGLLTSFIP | AQFLRLYQLL |
LFTLPGTPVF | SYGDELGLQA | VALPGQPMEA | PFMLWNESSN | SQTSSPVSLN |
MTVKGQNEDP | GSLLTQFRRL | SDLRGKERSL | LHGDFDALSS | SSGLFSYVRH |
WDQNERYLVV | LNFQDVGLSA | RVGASNLPAG | ISLPASANLL | LSTDSTRLSR |
EEGTSLSLEN | LSLNPYEGLL | LQFPFVA
"Ecto-phosphorylation of CD98 regulates cell-cell interactions."
"Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan."
"CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia."
"Beta1 integrins show specific association with CD98 protein in low density membranes."
"Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance."
"Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus."
"LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells."
"CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases."
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