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Eif4ebp2 (基因名), Eukaryotic translation initiation factor 4E-binding protein 2 (蛋白名), 4EBP2_MOUSE.
产品名称:

Mouse Eif4ebp2/ Eukaryotic translation initiation factor 4E-binding protein 2 CLIA Kit

货号:

U2694m

商标:
EIAab®
监管等级:
别名:

4E-BP2, Phosphorylated heat- and acid-stable protein regulated by insulin 2, PHAS-II

检测方法:
CLIA
特异性:
Natural and recombinant mouse Eukaryotic translation initiation factor 4E-binding protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Eif4ebp2 CLIA Kit
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产品说明书


通用注释


Sub Unit:
Hypophosphorylated EIF4EBP2 interacts with EIF4E; phosphorylation of EIF4EBP2 by mTORC1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:20347422, PubMed:23184952). Interacts with PCMT1; required to prevent isoaspartate accumulation and convert isoaspartate to Asp (PubMed:20424163).


Function:
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:16237163, PubMed:17029989). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:17029989, PubMed:20347422, PubMed:23172145). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (PubMed:20347422, PubMed:24139800, PubMed:23172145). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:8939971).


Subcellular Location:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2."

[2].
"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function."

[3].
"Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch."

[4].
"Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface."

[5].
"Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1."

[6].
"Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission."

[7].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[8].
"Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"."

[9].
"Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis."

[10].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
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