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Eif4ebp1 (基因名), Eukaryotic translation initiation factor 4E-binding protein 1 (蛋白名), 4EBP1_RAT.
产品名称:

Rat Eif4ebp1/ Eukaryotic translation initiation factor 4E-binding protein 1 CLIA Kit
4E-BP1

货号:

U2693r

商标:
EIAab®
监管等级:
别名:

4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I

检测方法:
CLIA
特异性:
Natural and recombinant rat Eukaryotic translation initiation factor 4E-binding protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Rat Eif4ebp1 CLIA Kit
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产品说明书


通用注释


Sub Unit:
Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7939721). Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1.


Function:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721).


Subcellular Location:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes."

[2].
"Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods."

[3].
"The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation."

[4].
"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action."

[5].
"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1."

[6].
"Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E."

[7].
"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function."

[8].
"Translational homeostasis via the mRNA cap-binding protein, eIF4E."

[9].
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."

[10].
"4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation."
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