EPB41 (基因名), Protein 4.1 (蛋白名), 41_HUMAN.
通用注释
Sub Unit:
Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions.
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
Subcellular Location:
Cytoplasm
Cytoskeleton
Cytoplasm
Cell cortex
Nucleus
数据库链接
验证序列:
该产品尚未在任何出版物中被引用。
[1].
"An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R."
[2].
"Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization."
[3].
"Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase."
[4].
"Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population."
[5].
"Marked difference in membrane-protein-binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation."
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