Hsd3b1 (基因名), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (蛋白名), 3BHS1_MOUSE.
产品名称:
Mouse Hsd3b1/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 CLIA Kit
滋养层细胞抗原3β
货号:
U2793m
商标:
EIAab®
监管等级:
别名:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, Hsd3b, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase
检测方法:
CLIA
特异性:
Natural and recombinant mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Metabolism
通用注释
Sub Unit:
N/A
Function:
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass membrane protein
Mitochondrion membrane
Single-pass membrane protein
数据库链接
验证序列:
该产品尚未在任何出版物中被引用。
[1].
"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."
[2].
"Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain."
[3].
"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."
[4].
"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."
[5].
"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."
[6].
"Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase."
[7].
"Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase."
[9].
"Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer."
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