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HSD3B1 (基因名), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (蛋白名), 3BHS1_HUMAN.

产品名称:

Human HSD3B1/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 CLIA Kit
滋养层细胞抗原3β

货号:

U2793h

商标:

EIAab^®

监管等级:

RUO

别名:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase, Trophoblast antigen FDO161G, 3-beta-HSD I, 3BH, HSDB3A

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Metabolism

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

N/A

功能:

A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).

亚细胞位置:

Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein

数据库链接

UniGene:

Hs.364941

STRING:

9606.ENSP00000358421

KEGG:

hsa:3283

MIM:

109715

Pfam: