HSD3B1 (基因名), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (蛋白名), 3BHS1_HUMAN.
Human HSD3B1/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 CLIA Kit
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3BH, HSDB3A, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase, Trophoblast antigen FDO161G
Natural and recombinant human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).
Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein
MTGWSCLVTG | AGGFLGQRII | RLLVKEKELK | EIRVLDKAFG | PELREEFSKL |
QNKTKLTVLE | GDILDEPFL | KRACQDVSVI | IHTACIIDVF | GVTHRESIMN |
VNVKGTQLLL | EACVQASVPV | F IYTSSIEV | AGPNSYKEII | QNGHEEEPLE |
NTWPAPYPHS | KKLAEKAVLA | ANGWNLKNGG | TL YTCALRP | MYIYGEGSRF |
LSASINEALN | NNGILSSVGK | FSTVNPVYVG | NVAWAHILAL | RAL QDPKKA |
PSIRGQFYYI | SDDTPHQSYD | NLNYTLSKEF | GLRLDSRWSF | PLSLMYWIGF |
LLEI VSFLL | RPIYTYRPPF | NRHIVTLSNS | VFTFSYKKAQ | RDLAYKPLYS |
WEEAKQKTVE | WVGSL VDRH | KETLKSKTQ
"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."
"Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain."
"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."
"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."
"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."
"Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase."
"Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase."
"Genetic susceptibility to distinct bladder cancer subphenotypes."
"Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer."
"A Large-scale genetic association study of esophageal adenocarcinoma risk."
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