PPP2R2D (基因名), Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (蛋白名), 2ABD_CHICK.
Chicken PPP2R2D/ Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform CLIA Kit
PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta, RCJMB04_22l15
Natural and recombinant chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity.
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
MAGVAGGGGN | GNDFQWCFSQ | VQGAVDEDVA | EADIISTVEF | NYSGDLLATG |
DKGGRVVIFQ | REQENKSRPH | SRGEYNVYST | FQSHEPEFDY | LKSLEIEEKI |
NKIRWLPQQN | AAHFLLSTND | KTIKLWKISE | RDKRAEGYNL | KDEDGRLRDP |
FKITALRVPI | LKPMDLMVEA | SPRRIFANAH | TYHINSISVN | SDHETYLSAD |
DLRINLWHLE | ITDRSFNIVD | IKPANMEELT | EVITAAEFHP | HHCNVFVYSS |
SKGTIRLCDM | RSSALCDRHS | KFFEEPEDPS | SRSFFSEIIS | SISDVKFSHS |
GRYMMTRDYL | SVKVWDLNME | NRPVETYQVH | EYLRSKLCSL | YENDCIFDKF |
ECCWNGSDGA | IMTGSYNNFF | RMFDRNTRRD | ITLEASRESS | KPRAILKPRK |
VCTGGKRKKD | EINVDSLDFN | KKILHTAWHP | MENIIAVAAT | NNLYIFQDKI |
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