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PPP2R1A (基因名), Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (蛋白名), 2AAA_PIG.

产品名称:

Pig PPP2R1A/ Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha

检测方法:

CLIA

特异性:

Natural and recombinant pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

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产品说明书

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通用注释

亚单元:

PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGO1. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with PLA2G16; this interaction might decrease PP2A activity. Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (By similarity). Interacts with CTTNBP2NL.

功能:

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.

亚细胞位置:

Cytoplasm Chromosome Centromere Centromeric localization requires the presence of BUB1.

数据库链接

UniGene:

Ssc.102

SMR:

P54612

STRING:

9823.ENSSSCP00000024131

KEGG:

ssc:397088

Pfam: