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Ywhaz (基因名), 14-3-3 protein zeta/delta (蛋白名), 1433Z_MOUSE.
产品名称:

Mouse Ywhaz/ 14-3-3 protein zeta/delta CLIA Kit
14-3-3蛋白ζ/δ

货号:

U14294m

商标:
EIAab®
监管等级:
别名:

Protein kinase C inhibitor protein 1, KCIP-1, SEZ-2

检测方法:
CLIA
特异性:
Natural and recombinant mouse 14-3-3 protein zeta/delta
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Mouse Ywhaz CLIA Kit
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Mouse Ywhaz CLIA Kit
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产品说明书


通用注释


Sub Unit:
Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with BSPRY. Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation (By similarity). Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 (By similarity). Interacts with SAMSN1. Interacts with BCL2L11 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (PubMed:22701344). Interacts with SLITRK1.


Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.


Subcellular Location:
Cytoplasm Melanosome Located to stage I to stage IV melanosomes.


该产品尚未在任何出版物中被引用。

[1].
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

[2].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[3].
"Examination of association of genes in the serotonin system to autism."

[4].
"Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study."

[5].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

[6].
"14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk."

[7].
"Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk."

[8].
"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon."

[9].
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."

[10].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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