YWHAZ (基因名), 14-3-3 protein zeta/delta (蛋白名), 1433Z_HUMAN.
Human YWHAZ/ 14-3-3 protein zeta/delta CLIA Kit
Protein kinase C inhibitor protein 1, KCIP-1
Natural and recombinant human 14-3-3 protein zeta/delta
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (PubMed:19640509).
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
MDKNELVQKA | KLAEQAERYD | DMAACMKSVT | EQGAELSNEE | RNLLSVAYKN |
VVGARRSSWR | VVSSIEQKTE | GAEKKQQMAR | EYREKIETEL | RDICNDVLSL |
LEKFLIPNAS | QAESKVFYLK | MKGDYYRYLA | EVAAGDDKKG | IVDQSQQAYQ |
EAFEISKKEM | QPTHPIRLGL | ALNFSVFYYE | ILNSPEKACS | LAKTAFDEAI |
AELDTLSEES | YKDSTLIMQL | LRDNLTLWTS | DTQGDEAEAG | EGGEN
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Examination of association of genes in the serotonin system to autism."
"Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk."
"Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk."
"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon."
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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