Sfn (基因名), 14-3-3 protein sigma (蛋白名), 1433S_MOUSE.
产品名称:
Mouse Sfn/ 14-3-3 protein sigma CLIA Kit
内皮细胞标记蛋白1
货号:
U15106m
商标:
EIAab®
监管等级:
别名:
Stratifin, Mkrn3
检测方法:
CLIA
实验类型:
Sandwich
特异性:
Natural and recombinant mouse 14-3-3 protein sigma
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2 (By similarity). Interacts with KRT17. Interacts with SAMSN1. Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with RFWD2; this interaction leads to proteasomal degradation (By similarity).Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (By similarity). Interacts with SLITRK1.
功能:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
亚细胞位置:
Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
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