YWHAH (基因名), 14-3-3 protein eta (蛋白名), 1433F_HUMAN.
Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
MGDREQLLQR | ARLAEQAERY | DDMASAMKAV | TELNEPLSNE | DRNLLSVAYK |
NVVGARRSSW | RVISSIEQKT | MADGNEKKLE | KVKAYREKIE | KELETVCNDV |
LSLLDKFLIK | NCNDFQYESK | VFYLKMKGDY | YRYLAEVASG | EKKNSVVEAS |
EAAYKEAFEI | SKEQMQPTHP | IRLGLALNFS | VFYYEIQNAP | EQACLLAKQA |
FDDAIAELDT | LNEDSYKDST | LIMQLLRDNL | TLWTSDQQDE | EAGEGN
"Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia."
"14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia."
"The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions."
"cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study."
"Family-based association of YWHAH in psychotic bipolar disorder."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"Structural basis for protein-protein interactions in the 14-3-3 protein family."
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