Ywhae (基因名), 14-3-3 protein epsilon (蛋白名), 1433E_MOUSE.
Homodimer (By similarity). Heterodimerizes with YWHAZ (By similarity). Interacts with PKA-phosphorylated AANAT (By similarity). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with ARHGEF28 (PubMed:11533041). Interacts with BEX3 (PubMed:11278287). Weakly interacts with CDKN1B (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with DENND1A (By similarity). Interacts with GAB2 (By similarity). Interacts with phosphorylated GRB10 (PubMed:15722337). Interacts with KSR1 (PubMed:10409742). Interacts with NDEL1 (PubMed:12796778). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with the phosphorylated (by AKT1) form of SRPK2 (By similarity). Interacts with TIAM2 (PubMed:17320046). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (PubMed:21078877). Interacts with SLITRK1 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.
Nucleus Cytoplasm Melanosome
MDDREDLVYQ | AKLAEQAERY | DEMVESMKKV | AGMDVELTVE | ERNLLSVAYK |
NVIGARRASW | RIISSIEQKE | ENKGGEDKLK | MIREYRQMVE | TELKLICCDI |
LDVLDKHLIP | AANTGESKVF | YYKMKGDYHR | YLAEFATGND | RKEAAENSLV |
AYKAASDIAM | TELPPTHPIR | LGLALNFSVF | YYEILNSPDR | ACRLAKAAFD |
DAIAELDTLS | EESYKDSTLI | MQLLRDNLTL | WTSDMQGDGE | EQNKEALQDV |
"KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing."
"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."
"Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Centrosome-related genes, genetic variation, and risk of breast cancer."
"Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia."
"Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis."
"Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes."
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
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