GPC1 (基因名), Glypican-1 (蛋白名), 10702_EIAAB.
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Secreted glypican-1 Secreted Extracellular space
MELRARGWWL | LCAAAALVAC | ARGDPASKSR | SCGEVRQIYG | AKGFSLSDVP |
QAEISGEHLR | ICPQGYTCCT | SEMEENLANR | SHAELETALR | DSSRVLQAML |
ATQLRSFDDH | FQHLLNDSER | TLQATFPGAF | GELYTQNARA | FRDLYSELRL |
YYRGANLHLE | ETLAEFWARL | LERLFKQLHP | QLLLPDDYLD | CLGKQAEALR |
PFGEAPRELR | LRATRAFVAA | RSFVQGLGVA | SDVVRKVAQV | PLGPECSRAV |
MKLVYCAHCL | GVPGARPCPD | YCRNVLKGCL | ANQADLDAEW | RNLLDSMVLI |
TDKFWGTSGV | ESVIGSVHTW | LAEAINALQD | NRDTLTAKVI | QGCGNPKVNP |
QGPGPEEKRR | RGKLAPRERP | PSGTLEKLVS | EAKAQLRDVQ | DFWISLPGTL |
CSEKMALSTA | SDDRCWNGMA | RGRYLPEVMG | DGLANQINNP | EVEVDITKPD |
MTIRQQIMQL | KIMTNRLRSA | YNGNDVDFQD | ASDDGSGSGS | GDGCLDDLCS |
RKVSRKSSSS | RTPLTHALPG | LSEQEGQKTS | AASCPQPPTF | LLPLLLFLAL |
"Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1."
"The structural role of N-linked glycans on human glypican-1."
"Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women."
"S-Nitrosylation of secreted recombinant human glypican-1."
"A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype."
"Correlation of glypican-1 expression with TGF-beta, BMP, and activin receptors in pancreatic ductal adenocarcinoma."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease."
"Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide."
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