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TAP (短名 ),
产品名称:

Mouse TAP/ Trypsinogen Activation Peptide,TAP CLIA Kit
胰蛋白酶激活肽

货号:

U0634m

商标:
EIAab®
监管等级:
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
19.5-1250pg/mL
特异性:
Natural and recombinant mouse Trypsinogen Activation Peptide,TAP
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse TAP CLIA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


Sub Unit:
N/A


Function:
Trypsinogen-activation peptide (TAP) is a small peptide that is released when trypsinogen is activated to trypsin. Under physiologic conditions, activation of trypsinogen occurs in the intestinal lumen and is catalyzed by enteropeptidase (formerly known as enterokinase). In the intestinal lumen, TAP is quickly degraded by peptidases of the brush border membrane. In pancreatitis, trypsinogen is prematurely activated within pancreatic acinar cells, and TAP is released into the peripheral circulation. Although TAP is quickly excreted through the kidneys, with a circulating half-life of less than 8 min, significant increases in plasma and urine TAP concentrations have been reported in canine and human patients with acute pancreatitis. An assay of TAP has been shown to be useful for the diagnosis and staging of pancreatitis in humans and dogs. Also, measurement of TAP in plasma and urine has been evaluated in experimental rodent and feline models of pancreatitis and has been shown to be useful in assessing pancreatic inflammation in those species.


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