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LTAD (短名 ),
产品名称:

General LTAD/ Lipoteichoic acid CLIA Kit
脂磷壁酸

货号:

U1405Ge

商标:
EIAab®
监管等级:
别名:

LTA

检测方法:
CLIA
实验类型:
Competitive
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant general Lipoteichoic acid
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
General LTAD CLIA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


Sub Unit:
N/A


Function:
LTA may bind to target cells non-specifically through membrane phospholipids, or specifically to CD14 and to Toll-like receptors. Binding to TLR-2 has shown to induce NF-κB expression(a central transcription factor), elevating expression of both pro- and anti-apoptotic genes. Its activation also induces mitogen-activated protein kinases (MAPK) activation along with Phosphoinositide 3-kinase activation.


Location:
Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria. These organisms have an inner (or cytoplasmic) membrane and, external to it, a thick (up to 80 nanometer) peptidoglycan layer. The structure of LTA varies between the different species of Gram positive bacteria and may contain long chains of ribitol or glycerol phosphate. LTA is anchored to the cell membrane via a glyceride. It acts as regulator of autolytic wall enzymes (muramidases). It has antigenic properties being able to stimulate specific immune response and is released from the bacterial cells mainly after bacteriolysis induced by lysozyme, cationic peptides from leucocytes, or beta-lactam antibiotics.


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