T4 (短名 ),
Thyroxine, or 3,5,3',5'-tetraiodothyronine (often abbreviated as T4), a form of thyroid hormones, is the major hormone secreted by the follicular cells of the thyroid gland.
Thyroxine is synthesized via the iodination and covalent bonding of the phenyl portions of tyrosine residues found in an initial peptide, thyroglobulin, which is secreted into thyroid granules. These iodinated diphenyl compounds are cleaved from their peptide backbone upon being stimulated by thyroid-stimulating hormone.
"Parental exposure to tebuconazole causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring"
SY Li, Q Wu, S Coffin, et al.
"Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae"
Liqin Yua, Jun Deng, Xiongjie Shi, Chunsheng Liu, Ke Yu, Bingsheng Zhou
"Perfluorooctane sulfonic acid exposure increases cadmium toxicity in early life stage of zebrafish, Danio rerio"
Suyoung Kim, Kyunghee Ji, Sangwoo Lee, Jinyoung Lee, Jungkon Kim, Sunmi Kim, Younglim Kho, Kyungho Choi
"Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae"
Jj Fu, Yy Guo, M Wang, et al.
C Liu, Y Wang, C Quan, M Yan, J Zhou, C Wang, K Yang
"Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish"
L Yu, JCW Lam, Y Guo, et al.
"Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish"
LQ Yu, GF Zhao, M Feng, et al.
"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring"
Zhihua H, Yuefei L, Shenghu Z, et al.
"Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae"
S Zhang, X Guo, S Lu, et al.
From: Environmental Pollution
"Embryonic exposure to soil samples from a gangue stacking area induces thyroid hormone disruption in zebrafish"
Fl Yang, Gk Li, N Sang.
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