Proinsulin (短名 ),
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.
Proinsulin is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin. Mature insulin has 35 fewer amino acids; 4 are removed altogether, and the remaining 31 form the C-peptide. The C-peptide is abstracted from the center of the proinsulin sequence; the two other ends (the B chain and A chain) remain connected by disulfide bonds.
"Association of type 2 diabetes susceptibility genes (TCF7L2,SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population"
Xiaoya Zheng Wei Ren Suhua Zhang Jingjing Liu Sufang Li Jinchao Li Ping Yang Jun He Shaochu Su Ping Li
From: Mol Biol Rep
"Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus"
XY Zheng, W Ren, SH Zhang, et al.
From: Acta Diabetol
评论数 : 0
规格 数量 价格 ($) 小计 1 ($)
小计 2: $
规格 数量 价格 ($)