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PON1 (基因名), Serum paraoxonase/arylesterase 1 (蛋白名), pon1_human.
产品名称:

Human PON1/ Serum paraoxonase/arylesterase 1 Recombinant Protein
血清对氧磷酶/芳基酯酶1

货号:

R0243h

商标:
EIAab®
监管等级:
别名:

Aromatic esterase 1, K-45, Serum aryldialkylphosphatase 1, A-esterase 1, PON 1, PON

序列号:
P27169
来源:
E.coli
种属:
Human
标签:
His
序列:
2-355aa
预估分子量:
38.94 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human PON1 Protein
规格 & 价格: cart
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Human PON1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7q21.3 by HGNC 7q21.3 by Entrez Gene 7q21.3 by Ensembl
PON1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.


功能:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.


亚细胞位置:
Secreted Extracellular space



[1].
Ramadan R· Tawdy A · Abdel Hay R · Rashed L · Tawfik D
From: Karger

[1].
"Serum oxidized low density lipoprotein, paraoxonase 1 and lipid peroxidation levels during oral glucose tolerance test."

[2].
"Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus."

[3].
"[Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease]."

[4].
"A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis."

[5].
"Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance."

[6].
"Activity of paraoxonase 1 and lipid profile in healthy children."

[7].
"Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile."

[8].
"Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas."

[9].
"Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method."

[10].
"Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes."
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