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MET (基因名), Hepatocyte growth factor receptor (蛋白名), met_human.
产品名称:

Human MET/ Hepatocyte growth factor receptor Recombinant Protein
肝细胞生长因子受体

货号:

R9559h

商标:
EIAab®
监管等级:
别名:

HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met, SF receptor, HGF receptor

序列号:
P08581
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MET Protein
规格 & 价格: cart
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Human MET Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7q31 by HGNC 7q31 by Entrez Gene 7q31 by Ensembl
MET Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with LECT2; this interaction may have an antagonistic effect on receptor activation (PubMed:27334921). Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity (PubMed:26517842).


功能:
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.


亚细胞位置:
Isoform 3 Secreted



[1].
"A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss."

[2].
"Ethnic differences and functional analysis of MET mutations in lung cancer."

[3].
"Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer."

[4].
"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."

[5].
"A genetic variant that disrupts MET transcription is associated with autism."
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