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SELP (基因名), P-selectin (蛋白名), lyam3_human.
产品名称:

Human SELP/ P-selectin Recombinant Protein
P选择素

货号:

R0115h

商标:
EIAab®
监管等级:
别名:

CD62 antigen-like family member P, Granule membrane protein 140, Leukocyte-endothelial cell adhesion molecule 3, Platelet activation dependent granule-external membrane protein, GMP-140, LECAM3, PADGEM, CD62P, GMRP, GRMP

序列号:
P16109
来源:
E.coli
种属:
Human
标签:
His
序列:
48-201aa
预估分子量:
16.94 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
  • Human SELP Protein
  • Human SELP Protein
  • Human SELP Protein
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Human SELP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
The sequence analysis of human SELP protein including hydrophilcity, hydrophobicity and antigenicity.
Human SELP Protein
The PCR product of human SELP gene was determined by 1% Agarose stained with EB.
Human SELP Protein
Recombinant human SELP protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 1q24.2 by HGNC 1q24.2 by Entrez Gene 1q24.2 by Ensembl
SELP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG.


功能:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.


亚细胞位置:
Cell membrane Single-pass type I membrane protein



[1].
"SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study."

[2].
"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."

[3].
"Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study."

[4].
"P-selectin polymorphisms' influences on P-selectin serum concentrations and on their familial correlation: the STANISLAS family study."

[5].
"Clinical and genetic correlates of soluble P-selectin in the community."
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