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KL (基因名), Klotho (蛋白名), klot_human.
产品名称:

Human KL/ Klotho Recombinant Protein
Klotho蛋白

货号:

R2253h

商标:
EIAab®
监管等级:
序列号:
Q9UEF7
来源:
E.coli
种属:
Human
标签:
His
序列:
34-218aa
预估分子量:
20.35 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human KL Protein
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Human KL Protein
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human KL Protein
Recombinant human KL protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 13q13.1 by HGNC 13q13.1 by Entrez Gene 13q13.1 by Ensembl
KL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with FGF23 and FGFR1.


功能:
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.


亚细胞位置:
Klotho peptide Secreted



[1].
"A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis."

[2].
"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity."

[3].
"Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women."

[4].
"Association of human aging with a functional variant of klotho."

[5].
"Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein."

[6].
"The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect."

[7].
"A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population."

[8].
"Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension."

[9].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[10].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
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