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Igf1 (基因名), Insulin-like growth factor I (蛋白名), igf1_mouse.
产品名称:

Mouse Igf1/ Insulin-like growth factor I Recombinant Protein
胰岛素样生长因子1

货号:

R0050m

商标:
EIAab®
监管等级:
别名:

Somatomedin, IGF-I, Igf-1

序列号:
P05017
来源:
E.coli
种属:
Mouse
标签:
His
序列:
49-118aa
预估分子量:
7.7 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Metabolism
  • Mouse Igf1 Protein
  • Mouse Igf1 Protein
  • Mouse Igf1 Protein
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Mouse Igf1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
The sequence analysis of mouse Igf1 protein including hydrophilcity, hydrophobicity and antigenicity.
Mouse Igf1 Protein
Recombinant mouse Igf1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.


功能:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (PubMed:21496647). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.


亚细胞位置:
Secreted


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