首页 > 重组蛋白 > Human ANXA2 Recombinant Protein

ANXA2 (基因名), Annexin A2 (蛋白名), anxa2_human.

产品名称:

Human ANXA2/ Annexin A2 Recombinant Protein
膜联蛋白A2

货号:

R1944h

商标:

EIAab^®

监管等级:

RUO

别名:

Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, Protein I, p36, PAP-IV, ANX2, ANX2L4, CAL1H, LPC2D

序列号:

P07355

来源:

E.coli

种属:

Human

标签:

His

序列:

139-339aa

预估分子量:

22.11 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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Human ANXA2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human ANXA2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 15q22.2 by HGNC 15q22.2 by Entrez Gene 15q22.2 by Ensembl

ANXA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

(Microbial infection) Interacts with human cytomegalovirus (HCMV).

功能:

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).

亚细胞位置:

Secreted Extracellular space Extracellular matrix Basement membrane Melanosome In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

数据库链接

UniGene:

Hs.511605

SMR:

P07355

STRING:

9606.ENSP00000346032

KEGG:

hsa:302

MIM:

151740

Pfam:

PF00191

Uniprot:

P07355

相关产品

Mouse Anxa2 ELISA Kit

Rat Anxa2 ELISA Kit

Bovine ANXA2 ELISA Kit

Chicken ANXA2 ELISA Kit

Pig ANXA2 ELISA Kit

序列长度:

339

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

339:

LKIRSEFKRK | YGKSLYYYIQ | QDTKGDYQKA | LLYLCGGDD

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"ANNALS EXPRESS: Annexin A2 and its Downstream IL-6 and HB-EGF as Secretory Biomarkers in the Differential Diagnosis of Her-2 Negative Breast Cancer"

Shetty P, Patil V S, Mohan R, et al.

From: Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine

[1].

"CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis."

(PMID: 14522961)

[2].

"The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein."

(PMID: 8636985)

[3].

"An endothelial cell-surface form of annexin II binds human cytomegalovirus."

(PMID: 8117306)

[4].

"The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha."

(PMID: 1825830)

[5].

"Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9."

(PMID: 24808179)

[6].

"Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation."

(PMID: 22848640)

[7].

"Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility."

(PMID: 21886777)

[8].

"Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147."

(PMID: 20047591)

[9].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[10].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[1].

人膜联蛋白A2(ANXA2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人膜联蛋白A2(ANXA2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人膜联蛋白A2(ANXA2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人膜联蛋白A2(ANXA2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人膜联蛋白A2(ANXA2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人膜联蛋白A2(ANXA2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人膜联蛋白A2(ANXA2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人膜联蛋白A2(ANXA2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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