首页 > 单抗 > CXCL12 Antibody

CXCL12 (基因名), Stromal cell-derived factor 1 (蛋白名), sdf1_human.

产品名称:

CXCL12 Antibody
基质细胞衍生因子1

货号:

M0477Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

C-X-C motif chemokine 12, Intercrine reduced in hepatomas, Pre-B cell growth-stimulating factor, IRH, PBSF, SDF-1, SDF1, SDF1A, SDF1B

反应性:

human

免疫原:

corresponding to a sequence mapping at the 22-93aa of P48061

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human CXCL12 Monoclonal Antibody

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R&D 技术数据

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通用注释

亚单元:

Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3.

功能:

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.522891

SMR:

P48061

STRING:

9606.ENSP00000379140

KEGG:

hsa:6387

MIM: