DKK1 (基因名), Dickkopf-related protein 1 (蛋白名), dkk1_human.
产品名称:
DKK1 Antibody
Dickkopf相关蛋白1
货号:
M0741Rb
商标:
EIAab®
监管等级:
别名:
SK, UNQ492/PRO1008, Dickkopf-1
反应性:
human,mouse,rat
免疫原:
corresponding to a sequence mapping at the 32-266aa of O94907
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cancer
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling.
功能:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
亚细胞位置:
Secreted
[1].
[2].
Delphine B. Maurela,Nathalie Boisseaub, Claude-Laurent Benhamou, Christelle Jaffré
From:
Joint Bone Spine
[4].
Mohamed F Z, Barakat L A A, Radwan N H, et al.
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