Vegfa (基因名), Vascular endothelial growth factor A (蛋白名), vegfa_rat.
产品名称:
Rat Vegfa/ Vascular endothelial growth factor A CLIA Kit
血管内皮生长因子A
货号:
U0143r
商标:
EIAab®
监管等级:
别名:
Vascular permeability factor, VPF, VEGF-A, Vegf
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
3.9-250pg/mL
特异性:
Natural and recombinant rat Vascular endothelial growth factor A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Cancer
通用注释
亚单元:
Homodimer; disulfide-linked. Also found as heterodimer with PGF. Interacts with NRP1 (By similarity).
功能:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
亚细胞位置:
Secreted
VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF-A188 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin (By similarity).
[3].
"Protective Effect of Platelet Rich Plasma on Experimental Ischemia/Reperfusion Injury in Rat Ovary"
Bakacak M, Bostanci M S, Inanc F, et al.
[4].
M Bakacak, Ö Ercan, B Köstü, et al.
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