Mouse Vegfa/ Vascular endothelial growth factor A CLIA Kit
血管内皮生长因子A

货号:

U0143m

商标:

EIAab^®

监管等级:

RUO

别名:

Vascular permeability factor, VPF, VEGF-A, Vegf

检测方法:

CLIA

特异性:

Natural and recombinant mouse Vascular endothelial growth factor A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Vegfa CLIA Kit

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通用注释

亚单元:

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).

功能:

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).

亚细胞位置:

Isoform VEGF-3 Cell membrane Peripheral membrane protein Remains cell-surface associated unless released by heparin.

数据库链接

UniGene:

Mm.282184

SMR:

Q00731

STRING:

10090.ENSMUSP00000115883

KEGG:

mmu:22339

Pfam: